pentobarbital will decrease the extent or impact of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.
Watch Intently (one)pentobarbital will decrease the level or impact of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Encouraged atogepant dosage with concomitant usage of potent or average CYP3A4 inducers is thirty mg or sixty mg qDay.
Observe Closely (1)pentobarbital will lessen the extent or result of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Warning when discontinuing CYP3A4 inducers which are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may well increase and may lead to perhaps lethal respiratory despair.
pentobarbital will lower the extent or outcome of tolterodine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Contraindicated (one)pentobarbital will lower the level or outcome of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females should not pick out estradiol valerate/dienogest as their contraceptive when employing powerful CYP3A4 inducers because of opportunity lessen in contraceptive efficacy.
Keep an eye on INR additional usually if coadministered with inducers of 戊巴比妥鈉製作 these isoenzymes and modify warfarin dose if needed.
pentobarbital will decrease the level or outcome of fosphenytoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.
pentobarbital will decrease the level or outcome of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not encouraged; powerful cytochrome P450 enzyme inducers lessen systemic publicity to roflumilast and will decrease the therapeutic effectiveness
Therapy must be administered with caution, if in the least, to patients that are mentally depressed, have suicidal tendencies, or heritage of drug abuse
pentobarbital will minimize the level or effect of cannabidiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Think about a rise in cannabidiol dosage (based upon medical response and tolerability) when coadministered with a robust CYP3A4 inducer.
pentobarbital will lessen the extent or result of nelfinavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital improves toxicity of methoxyflurane by expanding metabolism. Contraindicated. Amplified metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will reduce the extent or result of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.